SANT-1
| CAS No. | 304909-07-7 | Cat. No. | BCP08410 |
| Name | SANT-1 | ||
| Synonyms | SANT1;SANT 1; | ||
| Formula | C23H27N5 | M. Wt | 373.49 |
| Description | SANT-1 is a membrane permeable antagonist of the Shh signaling pathway by direct binding to Smo. This inhibition of Smo occurs equipotently by SANT-1 binding to both the oncogenic Smo and wild-type. When combined HDAC inhibitor SAHA, SANT-1 was able to suppress cellular proliferation and colony formation of Gemcitabine-resistant pancreatic adenocarcinoma cell lines Panc-1 and BxPC-3. | ||
| Pathways | GPCR/G Protein | ||
| Targets | Smoothened/Smo | ||
Structure
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