1-甲基-D-色氨酸
| CAS号 | 110117-83-4 | 货号 | BCP08015 |
| 中文名 | 1-甲基-D-色氨酸 | ||
| 英文名 | Indoximod | ||
| 中文别名 | |||
| 英文别名 | NLG-8189;NLG 8189;NLG8189;1-Methyl-D-tryptophan; | ||
| 分子式 | C12H14N2O2 | 分子量 | 218.25 |
| 生物活性 | 1-Methyl-D-tryptophan is an inhibitor of the enzymes IDO and INDOL1 (indolamine 2,3-dioxygenase 1 and 2) with selectivity for INDOL1. The enzymes perform similar transformations and are responsible for catalyzing the rate-limiting step of oxidative tryptophan catabolism in the kynurenine pathway. IDO activity is correlated with an induction of tolerance and immunosuppresion through activation of regulatory T cells by metabolites generated from tryptophan catabolism. Inhibition of IDO by 1-Methyl-D-tryptophan blocks this induced immune suppression, which has shown utility in suppressing acquired immunities of tumors and indicates potential for chemical intervention of chronic inflammatory diseases. | ||
| 信号通路 | Protease/Metabolic Enzyme | ||
| 靶 点 | IDO | ||
结构式
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