Lomeguatrib
| CAS No. | 192441-08-0 | Cat. No. | BCP07818 |
| Name | Lomeguatrib | ||
| Synonyms | PaTrin-2; | ||
| Formula | C10H8BrN5OS | M. Wt | 326.17 |
| Description | Inhibitor of O6-methylguanine-DNA methyltransferase (MGMT); (IC50 = 0.009 μM in cell-free extracts from HeLa S3 cells); attenuates MGMT activity in vitro and in vivo. Enhances the antitumor activity of temozolomide in both human melanoma and MCF-7 xenografts. | ||
| Pathways | Epigenetics | ||
| Targets | DNA Methyltransferase | ||
Structure
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