LCQ-908
| CAS No. | 956136-95-1 | Cat. No. | BCP21089 |
| Name | LCQ-908 | ||
| Synonyms | LCQ908; LCQ 908; Pradigastat; | ||
| Formula | C25H24F3N3O2 | M. Wt | 455.48 |
| Description | Pradigastat, also known as LCQ-908, is potent and oral DGAT1 inhibitor. Pradigastat is being developed for the treatment of familial chylomicronemia syndrome. Familial chylomicronemia syndrome (FCS) is a rare lipid disease caused by complete lipoprotein lipase (LPL) deficiency resulting in fasting chylomicronemia and severe hypertriglyceridemia. Inhibition of diacylglycerol acyltransferase 1 (DGAT1), which mediates chylomicron triglyceride (TG) synthesis, is an attractive strategy to reduce TG levels in FCS . | ||
| Pathways | Protease/Metabolic Enzyme | ||
| Targets | DGAT | ||
Structure
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