ONX-0914
| CAS No. | 960374-59-8 | Cat. No. | BCP07652 |
| Name | ONX-0914 | ||
| Synonyms | PR957; PR-957; PR 957; ONX0914; ONX 0914; | ||
| Formula | C31H40N4O7 | M. Wt | 580.67 |
| Description | ONX 0914 is an immunoproteasome inhibitor with potential treatment applications in autoimmune disorders, such as rheumatoid arthritis, inflammatory bowel disease and lupus. ONX 0914 was designed to be a potent inhibitor of the immunoproteasome with minimal cross-reactivity for the constitutive proteasome. Recent evidence suggests that the immunoproteasome regulates the production of several inflammatory cytokines, including Tumor Necrosis Factor-α (TNF-α), Interleukin-6 (IL-6), IL-17, and IL- | ||
| Pathways | Protease/Metabolic Enzyme | ||
| Targets | Proteasome | ||
Structure
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