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ONX-0914
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CAS No. | 960374-59-8 | Cat. No. | BCP07652 |
Name | ONX-0914 | ||
Synonyms | PR957; PR-957; PR 957; ONX0914; ONX 0914; | ||
SMILES | |||
Chemical Name | |||
Formula | C31H40N4O7 | M. Wt | 580.67 |
Purity | 95% | Storage | Store at 4-8°C |
Description | ONX 0914 is an immunoproteasome inhibitor with potential treatment applications in autoimmune disorders, such as rheumatoid arthritis, inflammatory bowel disease and lupus. ONX 0914 was designed to be a potent inhibitor of the immunoproteasome with minimal cross-reactivity for the constitutive proteasome. Recent evidence suggests that the immunoproteasome regulates the production of several inflammatory cytokines, including Tumor Necrosis Factor-α (TNF-α), Interleukin-6 (IL-6), IL-17, and IL- |
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