司美匹韦
| CAS号 | 923604-59-5 | 货号 | BCP07504 |
| 中文名 | 司美匹韦 | ||
| 英文名 | Simeprevir | ||
| 中文别名 | 西咪匹韦; | ||
| 英文别名 | TMC435350; TMC435; TMC-435350;TMC-435;TMC 435;TMC 435350;TMC435350;Olysio; | ||
| 分子式 | C38H47N5O7S2 | 分子量 | 749.94 |
| 生物活性 | Simeprevir is an orally bioavailable inhibitor of the hepatitis C virus (HCV) protease complex comprised of non-structural protein 3 and 4A (NS3/NS4A), with activity against HCV genotype 1. Upon administration, simeprevir reversibly binds to the active center and binding site of the HCV NS3/NS4A protease and prevents NS3/NS4A protease-mediated polyprotein maturation. This disrupts both the processing of viral proteins and the formation of the viral replication complex, which inhibits viral replication in HCV genotype 1-infected host cells. NS3, a serine protease, is essential for the proteolytic cleavage of multiple sites within the HCV polyprotein and plays a key role during HCV ribonucleic acid (RNA) replication. NS4A is an activating factor for NS3. HCV is a small, enveloped, single-stranded RNA virus belonging to the Flaviviridae family; HCV infection is associated with the development of hepatocellular carcinoma (HCC). | ||
| 信号通路 | Protease/Metabolic Enzyme Microbiology/Virology | ||
| 靶 点 | HCV Protease HCV | ||
|
Different Interaction Profiles of Direct-Acting Anti-Hepatitis C Virus Agents with Human Organic Anion Transporting Polypeptides
购于瀚香生物(Biochempartner)的司美匹韦(CAS:923604-59-5)被引用 |
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