司美匹韦新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP07504CAS号：923604-59-5纯度：98%

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CAS号	923604-59-5	货号	BCP07504
中文名	司美匹韦
英文名	Simeprevir
中文别名	西咪匹韦;
英文别名	TMC435350; TMC435; TMC-435350;TMC-435;TMC 435;TMC 435350;TMC435350;Olysio;
SMILES	CC1=C(C=CC2=C1N=C(C=C2OC3CC4C(C3)C(=O)N(CCCCC=CC5CC5(NC4=O)C(=O)NS(=O)(=O)C6CC6)C)C7=NC(=CS7)C(C)C)OC
化学名称
分子式	C38H47N5O7S2	分子量	749.94
纯度	98%	配送	惯例下常温包邮
产品描述	Simeprevir is an orally bioavailable inhibitor of the hepatitis C virus (HCV) protease complex comprised of non-structural protein 3 and 4A (NS3/NS4A), with activity against HCV genotype 1. Upon administration, simeprevir reversibly binds to the active center and binding site of the HCV NS3/NS4A protease and prevents NS3/NS4A protease-mediated polyprotein maturation. This disrupts both the processing of viral proteins and the formation of the viral replication complex, which inhibits viral replication in HCV genotype 1-infected host cells. NS3, a serine protease, is essential for the proteolytic cleavage of multiple sites within the HCV polyprotein and plays a key role during HCV ribonucleic acid (RNA) replication. NS4A is an activating factor for NS3. HCV is a small, enveloped, single-stranded RNA virus belonging to the Flaviviridae family; HCV infection is associated with the development of hepatocellular carcinoma (HCC).

司美匹韦 新