恩利卡生
| CAS号 | 254750-02-2 | 货号 | BCP07463 |
| 中文名 | 恩利卡生 | ||
| 英文名 | PF03491390 | ||
| 中文别名 | |||
| 英文别名 | Emricasan;IDN6556;IDN 6556;IDN-6556;PF-03491390;PF 03491390; | ||
| 分子式 | C26H27F4N3O7 | 分子量 | 569.5 |
| 生物活性 | Emricasan, also known as IDN 6556 and PF 03491390, is a first-in-class caspase inhibitor in clinical trials for the treatment of liver diseases. Emricasan (IDN-6556) decreases liver injury and fibrosis in a murine model of non-alcoholic steatohepatitis. IDN6556 facilitates marginal mass islet engraftment in a porcine islet autotransplant model. Oral IDN-6556 may lower aminotransferase activity in patients with chronic hepatitis C. Orally-administered PF-03491390 is retained in the liver for prolonged periods with low systemic exposure, exerting a hepatoprotective effect against alpha-fas-induced liver injury in a mouse model. | ||
| 信号通路 | Protease/Metabolic Enzyme Apoptosis Pathway | ||
| 靶 点 | Caspase | ||
结构式
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