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PF03491390 结构式

恩利卡生

参考资料 仅供科学研究，不可用于个人用途。
货号 ：BCP07463CAS号 ：254750-02-2纯度：98%
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  • 基本信息与产品描述
CAS号 254750-02-2 货号 BCP07463
中文名 恩利卡生
英文名 PF03491390
中文别名
英文别名 Emricasan;IDN6556;IDN 6556;IDN-6556;PF-03491390;PF 03491390;
SMILES
化学名称
分子式 C26H27F4N3O7 分子量 569.5
纯度 98% 配送 惯例下常温包邮
产品描述 Emricasan, also known as IDN 6556 and PF 03491390, is a first-in-class caspase inhibitor in clinical trials for the treatment of liver diseases. Emricasan (IDN-6556) decreases liver injury and fibrosis in a murine model of non-alcoholic steatohepatitis. IDN6556 facilitates marginal mass islet engraftment in a porcine islet autotransplant model. Oral IDN-6556 may lower aminotransferase activity in patients with chronic hepatitis C. Orally-administered PF-03491390 is retained in the liver for prolonged periods with low systemic exposure, exerting a hepatoprotective effect against alpha-fas-induced liver injury in a mouse model.
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