Disulfiram

CAS No.	97-77-8	Cat. No.	BCP07331
Name	Disulfiram
Synonyms	Tetraethylthiuram disulfide;TETD;Antabuse;NSC 190940; NSC190940; NSC-190940;
Formula	C10H20N2S4	M. Wt	296.54

Description	Disulfiram is a drug used to support the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. It blocks the processing of alcohol in the body by inhibiting acetaldehyde dehydrogenase, thus causing an unpleasant reaction when alcohol is consumed. Disulfiram should be used in conjunction with counseling and support. Disulfiram is also being studied as a treatment for cocaine dependence, as it prevents the breakdown of dopamine (a neurotransmitter whose release is stimulated by cocaine); the excess dopamine results in increased anxiety, higher blood pressure, restlessness, and other unpleasant symptoms. Several studies have reported that it has antiprotozoal activity, as well. Disulfiram is the subject of research for use in cancer therapy and as a treatment in HIV cure research (to activate the reservoir of HIV-infected resting CD4 cells) .
Pathways	Protease/Metabolic Enzyme
Targets	ALDH

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