RG108
| CAS No. | 48208-26-0 | Cat. No. | BCP06930 |
| Name | RG108 | ||
| Synonyms | N-Phthalyl-L-tryptophan; RG 108; RG-108; | ||
| Formula | C19H14N2O4 | M. Wt | 334.33 |
| Description | RG108 is a non-nucleoside DNA methyltransferase (DNMT) inhibitor. RG108 reactivates tumor suppressor gene expression (p16, SFRP1, secreted frizzled related protein-1, and TIMP-3) in tumor cells by DNA demethylation. RG108 also inhibits human tumor cell line (HCT116, NALM-6) proliferation and increased doubling time in culture. RG108 enhances the efficiency of induced pluripotent stem cell (iPS) generation. | ||
| Pathways | Epigenetics | ||
| Targets | DNA Methyltransferase | ||
Structure
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