CHR-6494
  • 化学数据
CAS号 1333377-65-3 货号 BCP06799
中文名 CHR-6494
英文名 CHR-6494
中文别名
英文别名 CHR6494;CHR 6494;
分子式 C16H16N6 分子量 292.34
  • 用途
生物活性 CHR-6494 is a first-in-class Haspin inhibitor with a wide spectrum of anticancer effects. Recent research showed that CHR-6494 reduces H3T3ph levels in a dose-dependent manner and causes a mitotic catastrophe characterized by metaphase misalignment, spindle abnormalities and centrosome amplification. From the cellular standpoint, the identified small-molecule Haspin inhibitor causes arrest in G2/M and subsequently apoptosis. Importantly, ex vivo assays also demonstrate its anti-angiogenetic features; in vivo, it shows antitumor potential in xenografted nude mice without any observed toxicity.
信号通路 Cell Cycle/DNA Damage 
靶 点 Haspin Kinase 

结构式

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