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CHR-6494 结构式

CHR-6494

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货号 ：BCP06799CAS号 ：1333377-65-3纯度：98%
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  • 基本信息与产品描述
CAS号 1333377-65-3 货号 BCP06799
中文名 CHR-6494
英文名 CHR-6494
中文别名
英文别名 CHR6494;CHR 6494;
SMILES
化学名称
分子式 C16H16N6 分子量 292.34
纯度 98% 配送 惯例下常温包邮
产品描述 CHR-6494 is a first-in-class Haspin inhibitor with a wide spectrum of anticancer effects. Recent research showed that CHR-6494 reduces H3T3ph levels in a dose-dependent manner and causes a mitotic catastrophe characterized by metaphase misalignment, spindle abnormalities and centrosome amplification. From the cellular standpoint, the identified small-molecule Haspin inhibitor causes arrest in G2/M and subsequently apoptosis. Importantly, ex vivo assays also demonstrate its anti-angiogenetic features; in vivo, it shows antitumor potential in xenografted nude mice without any observed toxicity.
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