Monastrol
| CAS No. | 329689-23-8 | Cat. No. | BCP06757 |
| Name | Monastrol | ||
| Synonyms | (±)-Monastrol; | ||
| Formula | C14H16N2O3S | M. Wt | 292.35 |
| Description | Monastrol is a kinesin Eg5 inhibitor. Induction of apoptosis by monastrol is independent of the spindle checkpoint. Monastrol binds to the KSP-ADP complex, forming a KSP-ADP- monastrol ternary complex, which cannot bind to microtubules productively and cannot undergo further ATP-driven conformational changes. | ||
| Pathways | Cell Cycle/DNA Damage | ||
| Targets | Kinesin | ||
Structure
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