PF-5274857
| CAS No. | 1373615-35-0 | Cat. No. | BCP06737 |
| Name | PF-5274857 | ||
| Synonyms | PF 5274857;PF5274857; | ||
| Formula | C20H25ClN4O3S | M. Wt | 436.96 |
| Description | PF-5274857 completely inhibits Shh-induced Hh pathway activity with IC50 of 2.7 nM measured by the transcriptional activity of Smo downstream gene Gli1 in MEF cells. The μ-opioid receptor is weakly inhibited by PF-5274857 with a dissociation constant of 36 μM subsequently determined in a functional assay. | ||
| Related Products | 1613439-62-5（PF-05274857 HCl） | ||
| Pathways | GPCR/G Protein Wnt/Stem Cell | ||
| Targets | Smoothened/Smo Hedgehog | ||
Structure
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