PF-05274857 HCl New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1613439-62-5 | Cat. No. | BCP48085 |
| Related Products | 1373615-35-0（PF-5274857） | ||
| Name | PF-05274857 HCl | ||
| Synonyms | PF-5274857 HCl; PF-5274857 hydrochloride;PF05274857 HCl;PF 05274857 HCl; PF-5274857 hydrochloride; | ||
| SMILES | CC1=CC(=C(N=C1)C2=CC(=NC=C2Cl)N3CCN(CC3)C(=O)CCS(=O)(=O)C)C.Cl | ||
| Chemical Name | |||
| Formula | C20H26Cl2N4O3S | M. Wt | 473.42 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | PF 5274857 hydrochloride is a high affinity and selective Smoothened (Smo) receptor antagonist (Ki = 4.6 nM). Exhibits >1000-fold selectivity for Smo over a panel of other receptors, ion channels and enzymes. Inhibits Shh-induced Hedgehog signaling in MEF cells. Induces tumor regression in a medulloblastoma allograft mouse model. Orally available and brain penetrant. | ||
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