MK-8245
| CAS号 | 1030612-87-3 | 货号 | BCP06568 |
| 中文名 | MK-8245 | ||
| 英文名 | MK-8245 | ||
| 中文别名 | |||
| 英文别名 | MK 8245;MK8245; | ||
| 分子式 | C16H15BrFN7O3S | 分子量 | 484.3 |
| 生物活性 | MK-8245 is a potent, liver-targeted SCD inhibitor with preclinical antidiabetic and antidyslipidemic efficacy with a significantly improved therapeutic window. MK-8245 was believed to inhibit the SCD enzyme solely in the liver and not in other tissues for the following reasons. When SCD inhibition has been measured by desaturation index in tissues of rodents treated with MK-8245, the desaturation index was significantly reduced in liver but not in other tissues such as skin, eye and adipose tissue. | ||
| 信号通路 | Protease/Metabolic Enzyme | ||
| 靶 点 | SCD | ||
结构式
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