雷西纳得
| CAS号 | 878672-00-5 | 货号 | BCP06435 |
| 中文名 | 雷西纳得 | ||
| 英文名 | RDEA594 | ||
| 中文别名 | 来司尼达; | ||
| 英文别名 | RDEA-594;RDEA 594;Lesinurad; | ||
| 分子式 | C17H14BrN3O2S | 分子量 | 404.28 |
| 生物活性 | in vivo: In healthy subjects, the combination of 40 mg FBX with RDEA-594 reduced sUA by approximately 70% at the 200 mg and 400 mg RDEA-594 dose levels, respectively. In gout patients, FBX 40 mg and 80 mg alone reduced sUA by 35% and 47%, respectively. FBX 40 mg + RDEA-594 reduced sUA by 56% and 61% when combined with RDEA-594 400 mg or 600 mg. respectively, resulting in response rates of 100% for sUA <6 and <5 mg/dl and 64% <4 mg/dl. FBX 80 mg + RDEA-594 reduced sUA by 65% and 73% when combined with RDEA-594 400 mg or 600 mg respectively. Following single dosing of RDEA594, exposure of RDEA594 was significantly higher than those obtained from RDEA 806 dosing, >5X at 20 mg/kg in rats and >10X at 30 mg/kg in monkeys. | ||
| 信号通路 | Ion Channel/Membrane Transporter | ||
| 靶 点 | URAT1 | ||
结构式
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