雷西纳得

参考资料仅供科学研究，不可用于个人用途。

货号：BCP06435CAS号：878672-00-5纯度：98%

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CAS号	878672-00-5	货号	BCP06435
中文名	雷西纳得
英文名	RDEA594
中文别名	来司尼达;
英文别名	RDEA-594;RDEA 594;Lesinurad;
SMILES
化学名称
分子式	C17H14BrN3O2S	分子量	404.28
纯度	98%	配送	惯例下常温包邮
产品描述	in vivo: In healthy subjects, the combination of 40 mg FBX with RDEA-594 reduced sUA by approximately 70% at the 200 mg and 400 mg RDEA-594 dose levels, respectively. In gout patients, FBX 40 mg and 80 mg alone reduced sUA by 35% and 47%, respectively. FBX 40 mg + RDEA-594 reduced sUA by 56% and 61% when combined with RDEA-594 400 mg or 600 mg. respectively, resulting in response rates of 100% for sUA <6 and <5 mg/dl and 64% <4 mg/dl. FBX 80 mg + RDEA-594 reduced sUA by 65% and 73% when combined with RDEA-594 400 mg or 600 mg respectively. Following single dosing of RDEA594, exposure of RDEA594 was significantly higher than those obtained from RDEA 806 dosing, >5X at 20 mg/kg in rats and >10X at 30 mg/kg in monkeys.