Gemcitabine Monophosphate
| CAS No. | 116371-67-6 | Cat. No. | BCP21656 |
| Name | Gemcitabine Monophosphate | ||
| Synonyms | 2'-Deoxy-2',2'-difluoro-5'-cytidylic Acid; | ||
| Formula | C9H12F2N3O7P | M. Wt | 343.18 |
| Description | Gemcitabine Monophosphate is a gemcitabine derivative. It is an antineoplastic agent.Gemcitabine (Gem) is a deoxycytidine analog that is effective against pancreatic cancer and other malignancies following conversion to the 5'-O-mono-, di- and tri-phosphate forms. GemMP decreased tumor cell growth at concentrations ranging from 1 to 50 nM. GemMP is a potent cytotoxic agent that serves to induce apoptosis in association with increased Fas expression in cultured thyroid cancer cell lines. | ||
| Pathways | Cell Cycle/DNA Damage | ||
| Targets | DNA/RNA Synthesis Antimetabolite | ||
Structure
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