Atopaxar
| CAS No. | 751475-53-3;943239-67-6 | Cat. No. | BCP05973 |
| Name | Atopaxar | ||
| Synonyms | E5555; E-5555; E 5555; ER-172594-00; ER172594-00; ER 172594-00; | ||
| Formula | C29H38FN3O5 | M. Wt | 527.64 |
| Description | Atopaxar, also known as E5555, is a potent and orally-active PAR-1 inhibitor. E5555 inhibited the binding of a high-affinity thrombin receptor-activating peptide ([(3)H]haTRAP) to PAR-1 with a half maximal inhibitory concentration (IC(50)) value of 0.019μM. E5555 showed potent inhibitory effects on human platelet aggregation induced by thrombin and TRAP with IC(50) values of 0.064 and 0.031μM, respectively. E5555 showed potent and selective inhibitory effects on guinea pig platelet aggregation induced by thrombin and TRAP with IC(50) values of 0.13 and 0.097μM, respectively. E5555 could be a therapeutic option for atherothrombotic disease. | ||
| Pathways | GPCR/G Protein | ||
| Targets | PAR | ||
Structure
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