Concanamycin A
CAS No. | 80890-47-7 | Cat. No. | BCP21840 |
Name | Concanamycin A | ||
Synonyms | X 4357 B; X-4357 B; X4357 B; NSC 674620;Antibiotic X 4357 B; | ||
Formula | C46H75NO14 | M. Wt | 866.1 |
Description | Concanamycin A is a specific inhibitor of V-type (vacuolar) H+-ATPase that displays > 2000-fold selectivity over other H+-ATPases (IC50 values are 9.2, > 20000, > 20000 and > 20000 nM for yeast V-type, F-type, P-type H+-ATPases and porcine P-type Na+,K+-ATPase respectively). Blocks cell surface expression of virus envelope glycoproteins without affecting synthesis and exhibits cytotoxicity in several cell lines. | ||
Pathways | Ion Channel/Membrane Transporter | ||
Targets | Proton Pump |
Structure
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