Concanamycin A
Data Sheet
For research use only. Not for human use.
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| CAS No. | 80890-47-7 | Cat. No. | BCP21840 |
| Name | Concanamycin A | ||
| Synonyms | X 4357 B; X-4357 B; X4357 B; NSC 674620;Antibiotic X 4357 B; | ||
| SMILES | CCC1C(C(CC(=CC=CC(C(OC(=O)C(=CC(=CC(C1O)C)C)OC)C(C)C(C(C)C2(CC(C(C(O2)C=CC)C)OC3CC(C(C(O3)C)OC(=O)N)O)O)O)OC)C)C)O | ||
| Chemical Name | |||
| Formula | C46H75NO14 | M. Wt | 866.1 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Concanamycin A is a specific inhibitor of V-type (vacuolar) H+-ATPase that displays > 2000-fold selectivity over other H+-ATPases (IC50 values are 9.2, > 20000, > 20000 and > 20000 nM for yeast V-type, F-type, P-type H+-ATPases and porcine P-type Na+,K+-ATPase respectively). Blocks cell surface expression of virus envelope glycoproteins without affecting synthesis and exhibits cytotoxicity in several cell lines. | ||
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