Ramelteon
| CAS No. | 196597-26-9 | Cat. No. | BCP04205 |
| Name | Ramelteon | ||
| Synonyms | TAK-375;Rozerem;TAK375;TAK 375; | ||
| Formula | C16H21NO2 | M. Wt | 259.34 |
| Description | Ramelteon inhibits forskolin-stimulated cAMP production with IC50 of 21.2 pM in CHO cells. Ramelteon has high affinity with recombinant human MT1 and MT2 receptors with pKi of 10.05 and 9.70, respectively. Ramelteon inhibits Xenopus laevis melanophore pigment granule aggregation with pEC50 of 11.48. Ramelteon (1 nM) increases ERK1/2 phosphorylation not only in MT1/MT2 cerebellar granule cells but also in cerebellar granule cells expressing only one of the two melatonin receptors. 4P-PDOT blocks the stimulatory action of Ramelteon (1 nM) in MT1 KO cerebellar granule cells, while luzindole attenuates the action of Ramelteon (1 nM) in MT2 KO cerebellar granule cells. Ramelteon (100 μM) induces any pigment dispersion while melatonin completely disperses aggregated melanophores at 10 μM. | ||
| Pathways | GPCR/G Protein | ||
| Targets | Melatonin Receptor | ||
Structure
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