RepSox
| CAS No. | 446859-33-2 | Cat. No. | BCP04103 |
| Name | RepSox | ||
| Synonyms | ALK5 Inhibitor II; E-616452;SJN 2511;E616452;SJN2511;E 616452;SJN-2511; | ||
| Formula | C17H13N5 | M. Wt | 287.32 |
| Description | RepSox, also known as SJN 2511, E 616452 and ALK5 Inhibitor II, is a cell permeable, selective inhibitor of the TGF-β type 1 activin like kinase receptor ALK5 (IC50s = 4, 18, and 23 nM for ALK5 autophosphorylation, TGF-β cellular assay, and ALK5 binding in HepG2 cells, respectively). RepSox slows decay of CD34+ acute myeloid leukemia cells and decreases T cell immunoglobulin mucin-3 expression. | ||
| Pathways | TGF beta/Smad | ||
| Targets | BMP/TGF beta Receptor | ||
Structure
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