Classified by application
All Products
Signaling Pathways
- Angiogenesis/Protein Tyrosine Kinase
- Apoptosis Pathway
- Cell Cycle/DNA Damage
- Epigenetics
-
GPCR/G Protein
- Urotensin Receptor
- Melatonin Receptor
- Neurotensin Receptor
- Glucose Transporter
- Motilin Receptor
- TGR5
- Cholecystokinin Receptor
- Adenylate Cyclase
- Somatostatin Receptor
- Oxytocin Receptor
- Bradykinin Receptor
- Guanylate Cyclase
- Melanocortin Receptor
- Imidazoline Receptor
- Neuropeptide Receptor
- PAR
- CRFR
- Sigma Receptor
- S1P Receptor
- GHSR
- PKA
- OX Receptor
- Adenosine Receptor
- Glucagon Receptor
- Prostaglandin Receptor
- NK Receptor
- GnRH Receptor
- Leukotriene Receptor
- Glucocorticoid Receptor
- mAChR
- P2 Receptor
- GPR
- CGRP Receptor
- CXCR
- Histamine Receptor
- CaSR
- Ras/Rho
- Vasopressin Receptor
- Smoothened/Smo
- mGluR
- Opioid Receptor
- Dopamine Receptor
- Cannabinoid Receptor
- Angiotensin Receptor
- Adrenergic Receptor
- SGLT
- Endothelin Receptor
- CCR
- 5 HT Receptor/Serotonin Receptor
- Hormone Pathay
- Ion Channel/Membrane Transporter
- Jak/Stat Pathway
- MAPK Pathway
- Microbiology/Virology
-
Neuro Signaling Pathway
- Imidazoline Receptor
- Monoamine Oxidase
- COMT
- Amyloid β
- NK Receptor
- Beta secretase
- AChE
- SSRI
- CaMK
- P glycoprotein
- Opioid Receptor
- Dopamine Receptor
- Adrenergic Receptor
- Histamine Receptor
- mGluR
- Gamma secretase
- Dopamine Transporter
- 5 HT Receptor/Serotonin Receptor
- P2 Receptor
- FAAH
- CGRP Receptor
- nAChR
- COX
- GABA Receptor
- mAChR
- NFκB
- PI3K/Akt/mTOR
-
Protease/Metabolic Enzyme
- COMT
- 11β HSD
- Carboxypeptidase
- ACC
- Xanthine Oxidase
- Pyruvate Kinase
- Mitochondrial Metabolism
- ALDH
- SCD
- Serine Protease
- MLR
- FTase
- CETP
- Neprilysin
- MAGL
- Carbonic Anhydrase
- E1 E2 E3 Enzyme
- Elastase
- PAI1
- NOX
- ROR
- Glucokinase
- Aldose Reductase
- Tyrosinase
- FAS
- DGAT
- Lipoxygenase
- Nampt
- IDO
- IDH
- MMP
- Cathepsin
- Phosphatase
- Thrombin
- FXR
- RAR/RXR
- HMGCR
- FAAH
- Gamma secretase
- RAAS/ACE
- Caspase
- HIV Protease
- Aminopeptidase
- HCV Protease
- HSP
- Tryptophan Hydroxylase/TPH
- Factor Xa
- DPP
- Procollagen C Proteinase
- Integrase
- Phosphodiesterase/PDE
- Phospholipase
- LXR
- Proteasome
- Cytochrome P450
- TGF beta/Smad
- Wnt/Stem Cell
- Others Pathway
Research Areas
- Metabolic Disease
- Neurological Disease
- Endocrinology
- Diabetes
- Cardiovascular Disease
- Immunology
- Allergy
- Inflammation
- Infection
- Cancer
Nature products
Antibodies
Peptides
Catalysts
Impurities
Intermediate
- Amino acid
- Ammonia Series
- Azaindazole
- Pyridazine Series
- Nucleoside Series
- Quinazoline
- Pyrazole Series
- Boric acid
- Pyrimidine Series
- Quinoline Series
- Pyrrole Series
- Thiophene Series
- Saccharide
- Azaindole
- Indole Series
- Piperidine Series
- Indazole Series
- Heterocyclic Series
- Benzene Series
- Pyridine Series
Raw Materials
BMP/TGF beta Receptor
Chemical Structure | Cat. No. | Product Name | CAS No. |
---|
BCP24138 | PD 161570 New | 192705-80-9 | |
PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC50 of 39.9 nM and a Ki of 42 nM. PD-161570 also inhibits the PDGFR, EGFR and c-Src tyrosine kinases with IC50 values of 310 nM, 240 nM, and 44 nM, respectively. PD-161570 inhibits PDGF-stimulated autophosphorylation and FGF-1 receptor phosphorylation with IC50s of 450 nM and 622 nM, respectively. PD-161570 is also a bone morphogenetic proteins (BMPs) and TGF-β signaling inhibitor.
|
BCP37563 | BMP signaling agonist sb4 New | 100874-08-6 | |
BMP signaling agonist sb4 is a potent and selective BMP4 signaling agonist with EC50 value of 74 nM. It enhances canonical BMP signaling and activates SMAD-1/5/9 phosphorylation.
|
BCP14671 | LDN-212854 New | 143259726-6 | |
LDN-212854 is a potent and selective BMP receptor inhibitor with IC50 of 1.3 nM for ALK2.
|
BCP30374 | SRI-011381 hydrochloride New | SRI011381HCl | |
SRI-011381 hydrochloride is a TGF-beta signaling agonist.
|
BCP30372 | SRI-011381 New | 1629138-41-5 | |
SRI-011381 is an agonist of the TGF-beta signaling pathway for treatment of Alzheimer's disease.
|
BCP30129 | BIO-013077-01 New | 746667-48-1 | |
BIO-013077-01 is a novel potent antagonist of the TGFbeta family type I receptors, Alk5 and/or Alk4.
|
BCP29880 | SJ000291942 | 425613-09-8 | |
SJ000291942 is an activator of the canonical bone morphogenetic proteins (BMP) signaling pathway.
|
BCP20431 | LDN-193189 2HCl | 1435934-00-1 | |
LDN193189 is a highly potent small molecule BMP inhibitor with IC50 of 5 and 30 nM for ALK2 and ALK3, respectively.
|
BCP13726 | A 77-01 | 607737-87-1 | |
A 77-01 is a potent inhibitor of TGF-β type I receptor superfamily activin-like kinase ALK5 with IC50 of 25 nM.
|
BCP12392 | LDN-214117 | 1627503-67-6 | |
LDN-214117 is a selective inhibitor of the bone morphogenetic protein (BMP) type I receptor kinases with high selectivity for BMP versus TGF-β signaling, and low cytotoxicity.
|