Manidipine dihydrochloride

CAS No.	89226-75-5	Cat. No.	BCP22692
Name	Manidipine dihydrochloride
Synonyms	CV-4093;CV 4093;CV4093;Manidipine 2HCl;126229-12-7;
Formula	C35H40Cl2N4O6	M. Wt	683.62

Description	Manidipine, also known as CV-4093, is a calcium channel blocker (dihydropyridine type) that is used clinically as an antihypertensive. Manidipine is a lipophilic, third-generation dihydropyridine calcium channel antagonist with a high degree of selectivity for the vasculature, thereby inducing marked peripheral vasodilation with negligible cardiodepression. In addition, manidipine does not significantly affect norepinephrine levels, suggesting a lack of sympathetic activation. Manidipine has shown antihypertensive efficacy and appears to be well tolerated in adult and elderly patients with mild or moderate essential hypertension.
Pathways	Ion Channel/Membrane Transporter
Targets	Calcium Channel

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