Alvespimycin HCl

CAS No.	467214-21-7	Cat. No.	BCP22705
Name	Alvespimycin HCl
Synonyms	Alvespimycin hydrochloride;17-DMAG hydrochloride; KOS1022; KO-S1022; KOS 1022;BMS 826476;17 DMAG;17DMAG;7-DMAG HCl;
Formula	C32H48N4O8.HCl	M. Wt	653.21

Description	Alvespimycin is an analogue of the antineoplastic benzoquinone antibiotic geldanamycin. Alvespimycin binds to HSP90, a chaperone protein that aids in the assembly, maturation and folding of proteins. Subsequently, the function of Hsp90 is inhibited, leading to the degradation and depletion of its client proteins such as kinases and transcription factors involved with cell cycle regulation and signal transduction. Check for active clinical trials or closed clinical trials using this agent.
Pathways	Protease/Metabolic Enzyme Cell Cycle/DNA Damage
Targets	HSP

Part data of this page collected from the open network resources, so Biochempartner can not guarantee its accuracy.

For product details of different batches, please contact our Customer

Products are for research use only and not for human use. We do not sell to patients.