Alvespimycin HCl New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 467214-21-7 | Cat. No. | BCP22705 |
| Name | Alvespimycin HCl | ||
| Synonyms | Alvespimycin hydrochloride;17-DMAG hydrochloride; KOS1022; KO-S1022; KOS 1022;BMS 826476;17 DMAG;17DMAG;7-DMAG HCl; | ||
| SMILES | CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCCN(C)C)C)OC)OC(=O)N)C)C)O)OC.Cl | ||
| Chemical Name | |||
| Formula | C32H48N4O8.HCl | M. Wt | 653.21 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Alvespimycin is an analogue of the antineoplastic benzoquinone antibiotic geldanamycin. Alvespimycin binds to HSP90, a chaperone protein that aids in the assembly, maturation and folding of proteins. Subsequently, the function of Hsp90 is inhibited, leading to the degradation and depletion of its client proteins such as kinases and transcription factors involved with cell cycle regulation and signal transduction. Check for active clinical trials or closed clinical trials using this agent. | ||
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