奥沙利铂
| CAS号 | 61825-94-3 | 货号 | BCP22716 |
| 中文名 | 奥沙利铂 | ||
| 英文名 | Oxaliplatin | ||
| 中文别名 | 己草铂;左旋反式二氨环己烷草酸铂; | ||
| 英文别名 | |||
| 分子式 | C8H12N2O4Pt | 分子量 | 397.29 |
| 生物活性 | Oxaliplatin is an organoplatinum complex in which the platinum atom is complexed with 1,2-diaminocyclohexane (DACH) and with an oxalate ligand as a 'leaving group.' A 'leaving group' is an atom or a group of atoms that is displaced as a stable species taking with it the bonding electrons. After displacement of the labile oxalate ligand leaving group, active oxaliplatin derivatives, such as monoaquo and diaquo DACH platinum, alkylate macromolecules, forming both inter- and intra-strand platinum-DNA crosslinks, which result in inhibition of DNA replication and transcription and cell-cycle nonspecific cytotoxicity. The DACH side chain appears to inhibit alkylating-agent resistance. Check for active clinical trials or closed clinical trials using this agent. | ||
| 信号通路 | Cell Cycle/DNA Damage | ||
| 靶 点 | DNA Alkylator/Crosslinker | ||
结构式
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