卡铂
| CAS号 | 41575-94-4 | 货号 | BCP22717 |
| 中文名 | 卡铂 | ||
| 英文名 | Carboplatin | ||
| 中文别名 | |||
| 英文别名 | cis-Diammine(1,1-cyclobutanedicarboxylato)platinum; | ||
| 分子式 | C6H12N2O4Pt | 分子量 | 371.25 |
| 生物活性 | Carboplatin is a second-generation platinum compound with a broad spectrum of antineoplastic properties. Carboplatin contains a platinum atom complexed with two ammonia groups and a cyclobutane-dicarboxyl residue. This agent is activated intracellularly to form reactive platinum complexes that bind to nucleophilic groups such as GC-rich sites in DNA, thereby inducing intrastrand and interstrand DNA cross-links, as well as DNA-protein cross-links. These carboplatin-induced DNA and protein effects result in apoptosis and cell growth inhibition. | ||
| 信号通路 | Cell Cycle/DNA Damage | ||
| 靶 点 | DNA Alkylator/Crosslinker | ||
结构式
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