氯硝柳胺
| CAS号 | 50-65-7 | 货号 | BCP22958 |
| 中文名 | 氯硝柳胺 | ||
| 英文名 | Niclosamide | ||
| 中文别名 | |||
| 英文别名 | Niclocide;BAY 2353; NSC 178296; WR 46234; BAY-2353; NSC-178296; WR-46234; BAY2353; NSC178296; WR46234; | ||
| 分子式 | C13H8Cl2N2O4 | 分子量 | 327.12 |
| 生物活性 | Niclosamide is an oral antihelminthic drug, which has been used to treat tapeworm infection for about 50 years. Niclosamide is also used as a molluscicide for water treatment in schistosomiasis control programs. Recently, several groups have independently discovered that niclosamide is also active against cancer cells. Evidence supports that niclosamide targets multiple signaling pathways (NF-κB, Wnt/β-catenin, Notch, ROS, mTORC1, and Stat3), most of which are closely involved with cancer stem cells. Given its potential antitumor activity, clinical trials for niclosamide and its derivatives are warranted for cancer treatment. | ||
| 信号通路 | Jak/Stat Pathway Wnt/Stem Cell | ||
| 靶 点 | Stat | ||
结构式
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