替莫唑胺
| CAS号 | 85622-93-1 | 货号 | BCP03692 |
| 中文名 | 替莫唑胺 | ||
| 英文名 | Temozolomide | ||
| 中文别名 | 3-甲基-4-氧代-8-咪唑并[5,1-d][1,2,3,5]四嗪甲酰胺; | ||
| 英文别名 | SCH-52365; SCH52365; SCH 52365; MB39831; MB-39831; MB 39831; RP46161; RP 46161; R-P46161; CCRG81045; TMZ; | ||
| 分子式 | C6H6N6O2 | 分子量 | 194.15 |
| 生物活性 | Temozolomide, also known as SCH 52365 , MB39831, and RP46161, is a triazene analog of dacarbazine with antineoplastic activity. As a cytotoxic alkylating agent, temozolomide is converted at physiologic pH to the short-lived active compound, monomethyl triazeno imidazole carboxamide (MTIC). The cytotoxicity of MTIC is due primarily to methylation of DNA at the O6 and N7 positions of guanine, resulting in inhibition of DNA replication. Unlike dacarbazine, which is metabolized to MITC only in the liver, temozolomide is metabolized to MITC at all sites. Temozolomide is administered orally and penetrates well into the central nervous system. | ||
| 信号通路 | Cell Cycle/DNA Damage | ||
| 靶 点 | DNA Alkylator/Crosslinker | ||
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Suppression of glioblastoma by a drug cocktail reprogramming tumor cells into neuronal like cells
购于瀚香生物(Biochempartner)的替莫唑胺(CAS:85622-93-1)被引用 |
结构式
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