替莫唑胺

参考资料仅供科学研究，不可用于个人用途。

货号：BCP03692CAS号：85622-93-1纯度：98%

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Sci Rep. 2019; 9: 3462.

CAS号	85622-93-1	货号	BCP03692
中文名	替莫唑胺
英文名	Temozolomide
中文别名	3-甲基-4-氧代-8-咪唑并[5,1-d][1,2,3,5]四嗪甲酰胺;
英文别名	SCH-52365; SCH52365; SCH 52365; MB39831; MB-39831; MB 39831; RP46161; RP 46161; R-P46161; CCRG81045; TMZ;
SMILES
化学名称
分子式	C6H6N6O2	分子量	194.15
纯度	98%	配送	惯例下常温包邮
产品描述	Temozolomide, also known as SCH 52365 , MB39831, and RP46161, is a triazene analog of dacarbazine with antineoplastic activity. As a cytotoxic alkylating agent, temozolomide is converted at physiologic pH to the short-lived active compound, monomethyl triazeno imidazole carboxamide (MTIC). The cytotoxicity of MTIC is due primarily to methylation of DNA at the O6 and N7 positions of guanine, resulting in inhibition of DNA replication. Unlike dacarbazine, which is metabolized to MITC only in the liver, temozolomide is metabolized to MITC at all sites. Temozolomide is administered orally and penetrates well into the central nervous system.