福他替尼二钠盐
| CAS号 | 1025687-58-4 | 货号 | BCP02850 |
| 中文名 | 福他替尼二钠盐 | ||
| 英文名 | Fostamatinib disodium | ||
| 中文别名 | Fostamatinib 二钠盐; | ||
| 英文别名 | prodrug of R-406;R935788 sodium;R-788;R 788;R788 disodium;R935788; R-935788; R 935788; | ||
| 分子式 | C23H24FN6O9P.2Na | 分子量 | 624.42 |
| 生物活性 | Fostamatinib Disodium Anhydrous is the anhydrous form of fostamatinib disodium, an orally available Syk kinase inhibitor with potential anti-inflammatory and immunomodulating activities. R935788 is a methylene phosphate prodrug of R406, which can be rapidly converted to R406 in vivo. R406 (in vitro active form of R935788) selectively inhibits Syk-dependent signaling with EC50 values ranging from 33 nM to 171 nM, more potently than Syk-independent pathways in different cells.R406 inhibits cellular proliferation of a variety of diffuse large B-cell lymphoma (DLBCL) cell lines with EC50 values ranging from 0.8 μM to 8.1 μM.R406 treatment reduces basal phosphorylation of BLNK, Akt, glycogen synthase kinase-3 (GSK-3), forkhead box O (FOXO) and ERK not only in cells with high (TCL-002) but also in cells with low levels of phosphorylated Syk (TCL1-551). | ||
| 上下游产品 | 901119-35-5（福他替尼） 914295-16-2（福他替尼钠盐水合物） | ||
| 信号通路 | Angiogenesis/Protein Tyrosine Kinase | ||
| 靶 点 | Syk | ||
结构式
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