喜树碱
| CAS号 | 7689-03-4 | 货号 | BCP02857 |
| 中文名 | 喜树碱 | ||
| 英文名 | Camptothecin | ||
| 中文别名 | |||
| 英文别名 | Camptothecine (S,+);(S)-(+)-Camptothecin; d-Camptothecin; 20(S)-Camptothecine; (+)-Camptothecin; Camptothecine; CPT; | ||
| 分子式 | C20H16N2O4 | 分子量 | 348.35 |
| 生物活性 | Camptothecin (CPT) is a cytotoxic quinoline alkaloid which inhibits the DNA enzyme topoisomerase I (topo I). It was discovered in 1966 by M. E. Wall and M. C. Wani in systematic screening of natural products for anticancer drugs. It was isolated from the bark and stem of Camptotheca acuminata (Camptotheca, Happy tree), a tree native to China used as a cancer treatment in Traditional Chinese Medicine. CPT showed remarkable anticancer activity in preliminary clinical trials but also low solubility and (high) adverse drug reaction. Because of these disadvantages synthetic and medicinal chemists have developed numerous syntheses of Camptothecin and various derivatives to increase the benefits of the chemical, with good results. Two CPT analogues have been approved and are used in cancer chemotherapy today, topotecan and irinotecan. | ||
| 信号通路 | Cell Cycle/DNA Damage Others Pathway | ||
| 靶 点 | Topoisomerase ADC Related | ||
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Using Amphiphilic Polymer Micelles as the Templates of Antisolvent Crystallization to Produce Drug Nanocrystals
购于瀚香生物(Biochempartner)的喜树碱(CAS:7689-03-4)被引用 |
结构式
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