LY2109761
| CAS号 | 700874-71-1 | 货号 | BCP02824 |
| 中文名 | LY2109761 | ||
| 英文名 | LY2109761 | ||
| 中文别名 | |||
| 英文别名 | LY-2109761;LY 2109761; | ||
| 分子式 | C26H27N5O2 | 分子量 | 441.52 |
| 生物活性 | LY2109761 treatment induces a dose-dependent low-anchorage growth inhibition of L3.6pl/GLT cells, leading to ~33% or 73% inhibition at 2 μM and 20 μM, respectively, which can be strongly enhanced when combined with gemcitabine in combination index value of 0.36581. Blocking TβRI/II kinase activity with LY2109761 (5 μM) completely suppresses both the basal and TGF-β1-stimulated migration and invasion of L3.6pl/GLT cells, significantly enhances the detachment-induced apoptosis by 26% at 8 hours treatment, and completely suppresses TGF-β–induced Smad2 phosphorylation.LY2109761 treatment at 1 nM is sufficient to significantly block the migration and invasion but not adhesion of hepatocellular carcinoma cells by increasing E-cadherin expression.LY2109761 pretreatment enhances radiosensitivity of glioblastoma cells via TGF-β signaling blockage. LY2109761 (10 μM) reduces the self-renewal and proliferation of GBM-derived cancer stem–like cells (CSLC), which can be significantly enhanced when c | ||
| 信号通路 | TGF beta/Smad Wnt/Stem Cell | ||
| 靶 点 | BMP/TGF beta Receptor TGF β/Smad | ||
结构式
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