盐酸埃罗替尼
| CAS号 | 183319-69-9 | 货号 | BCP02600 |
| 中文名 | 盐酸埃罗替尼 | ||
| 英文名 | Erlotinib HCl | ||
| 中文别名 | 伊诺替尼盐酸盐; | ||
| 英文别名 | Erlotinib hydrochloride;CP-358774 HCl;CP 358774 HCl;CP358774 HCl;OSI-774 HCl;OSI 774 HCl;OSI774 HCl; | ||
| 分子式 | C22H23N3O4.HCl | 分子量 | 429.9 |
| 生物活性 | Erlotinib HCl potently inhibits EGFR activation in intact cells including HNS human head and neck tumor cells (IC50 20nM), DiFi humancolon cancer cells andMDA MB-468 human breast cancer cells. Erlotinib HCl (1 μM) induces apoptosis in DiFi humancolon cancer cells.Erlotinib inhibits growth of a panel of NSCLC cell lines including A549, H322, H3255, H358 H661, H1650, H1975, H1299, H596 with IC50 ranging from 29 nM to >20 μM.Erlotinib HCl(2 μM) significantly inhibits growth of AsPC-1 and BxPC-3 pancreatic cells.The effects of Erlotinib HCl in combination with gemcitabine are considered additive in KRAS-mutated pancreatic cancer cells. Ten micromolar of Erlotinib HCl inhibits EGFR phospho-rylation at the Y845 (Src-dependent phosphorylation) and Y1068 (auto-phosphorylation) sites. Combination with Erlotinib HCl could down-modulate rapamycin-stimulated Akt activity and produces a synergistic effect on cell growth inhibition. | ||
| 上下游产品 | 183321-74-6（埃罗替尼） | ||
| 信号通路 | Angiogenesis/Protein Tyrosine Kinase Jak/Stat Pathway | ||
| 靶 点 | EGFR | ||
结构式
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