盐酸埃罗替尼新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP02600CAS号：183319-69-9纯度：98%

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CAS号	183319-69-9	货号	BCP02600
关联产品	183321-74-6（埃罗替尼）
中文名	盐酸埃罗替尼
英文名	Erlotinib HCl
中文别名	伊诺替尼盐酸盐;
英文别名	Erlotinib hydrochloride;CP-358774 HCl;CP 358774 HCl;CP358774 HCl;OSI-774 HCl;OSI 774 HCl;OSI774 HCl;
SMILES
化学名称
分子式	C22H23N3O4.HCl	分子量	429.9
纯度	98%	配送	惯例下常温包邮
产品描述	Erlotinib HCl potently inhibits EGFR activation in intact cells including HNS human head and neck tumor cells (IC50 20nM), DiFi humancolon cancer cells andMDA MB-468 human breast cancer cells. Erlotinib HCl (1 μM) induces apoptosis in DiFi humancolon cancer cells.Erlotinib inhibits growth of a panel of NSCLC cell lines including A549, H322, H3255, H358 H661, H1650, H1975, H1299, H596 with IC50 ranging from 29 nM to >20 μM.Erlotinib HCl(2 μM) significantly inhibits growth of AsPC-1 and BxPC-3 pancreatic cells.The effects of Erlotinib HCl in combination with gemcitabine are considered additive in KRAS-mutated pancreatic cancer cells. Ten micromolar of Erlotinib HCl inhibits EGFR phospho-rylation at the Y845 (Src-dependent phosphorylation) and Y1068 (auto-phosphorylation) sites. Combination with Erlotinib HCl could down-modulate rapamycin-stimulated Akt activity and produces a synergistic effect on cell growth inhibition.

盐酸埃罗替尼 新