Rapamycin
| CAS No. | 53123-88-9 | Cat. No. | BCP01404 |
| Name | Rapamycin | ||
| Synonyms | Sirolimus;Rapamune; AY 22989; AY22989; AY-22989; WY090217; WY-090217; WY 090217; | ||
| Formula | C51H79NO13 | M. Wt | 914.18 |
| Description | Rapamycin is a natural macrocyclic lactone produced by the bacterium Streptomyces hygroscopicus, with immunosuppressant properties. In cells, sirolimus binds to the immunophilin FK Binding Protein-12 (FKBP-12) to generate an immunosuppressive complex that binds to and inhibits the activation of the mammalian Target Of Rapamycin (mTOR), a key regulatory kinase. This results in inhibition of T lymphocyte activation and proliferation that occurs in response to antigenic and cytokine (IL-2, IL-4, and IL-15) stimulation and inhibition of antibody production. | ||
| Pathways | Others Pathway PI3K/Akt/mTOR | ||
| Targets | Autophagy mTOR | ||
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A novel lead compound CM-118: Antitumor activity and new insight into the molecular mechanism and combination therapy strategy in c-Met- and ALK-dependent cancers
Publications Citing of Biochempartner's Rapamycin(CAS:53123-88-9) |
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Molecular regulation of apoptotic machinery and lipid metabolism by mTORC1/mTORC2 dual inhibitors in preclinical models of HER2+/PIK3CAmut breast cancer
Publications Citing of Biochempartner's Rapamycin(CAS:53123-88-9) |
Structure
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