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Rapamycin Chemical Structure

Rapamycin

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP01404CAS No. ：53123-88-9Purity：98%
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  • Publications Citing of Biochempartner's Rapamycin
Cancer Biol Ther. 2014 Jun 1; 15(6): 721–734. Oncotarget. 2016 Oct 11; 7(41): 67071–67086.
Med Sci Monit. 2017; 23: 801–808. Int J Biol Sci. 2022; 18(3): 1107–1119.
Front Oncol. 2020; 10: 1615. Oncotarget. 2016 May 3; 7(18): 25224–25240.
  • Chemical Properties&Biological Activity
CAS No. 53123-88-9 Cat. No. BCP01404
Name Rapamycin
Synonyms Sirolimus;Rapamune; AY 22989; AY22989; AY-22989; WY090217; WY-090217; WY 090217;
SMILES C[C@@H](C([C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(C[C@@H]([C@H](C)C[C@@H]1CC[C@@H](O)C(OC)C1)OC2=O)=O)=O)C[C@H](C)/C=C/C=C/C=C(C)/[C@@H](OC)C[C@H]3O[C@](C(C(N4[C@H]2CCCC4)=O)=O)(O)[C@H](C)CC3
Chemical Name
Formula C51H79NO13 M. Wt 914.18
Purity 98% Storage Store at 4-8°C
Description Rapamycin is a natural macrocyclic lactone produced by the bacterium Streptomyces hygroscopicus, with immunosuppressant properties. In cells, sirolimus binds to the immunophilin FK Binding Protein-12 (FKBP-12) to generate an immunosuppressive complex that binds to and inhibits the activation of the mammalian Target Of Rapamycin (mTOR), a key regulatory kinase. This results in inhibition of T lymphocyte activation and proliferation that occurs in response to antigenic and cytokine (IL-2, IL-4, and IL-15) stimulation and inhibition of antibody production.
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H-NMR HPLC
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