雷帕霉素
| CAS号 | 53123-88-9 | 货号 | BCP01404 |
| 中文名 | 雷帕霉素 | ||
| 英文名 | Rapamycin | ||
| 中文别名 | 西罗莫司; | ||
| 英文别名 | Sirolimus;Rapamune; AY 22989; AY22989; AY-22989; WY090217; WY-090217; WY 090217; | ||
| 分子式 | C51H79NO13 | 分子量 | 914.18 |
| 生物活性 | Rapamycin is a natural macrocyclic lactone produced by the bacterium Streptomyces hygroscopicus, with immunosuppressant properties. In cells, sirolimus binds to the immunophilin FK Binding Protein-12 (FKBP-12) to generate an immunosuppressive complex that binds to and inhibits the activation of the mammalian Target Of Rapamycin (mTOR), a key regulatory kinase. This results in inhibition of T lymphocyte activation and proliferation that occurs in response to antigenic and cytokine (IL-2, IL-4, and IL-15) stimulation and inhibition of antibody production. | ||
| 信号通路 | Others Pathway PI3K/Akt/mTOR | ||
| 靶 点 | Autophagy mTOR | ||
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A novel lead compound CM-118: Antitumor activity and new insight into the molecular mechanism and combination therapy strategy in c-Met- and ALK-dependent cancers
购于瀚香生物(Biochempartner)的雷帕霉素(CAS:53123-88-9)被引用 |
|
Molecular regulation of apoptotic machinery and lipid metabolism by mTORC1/mTORC2 dual inhibitors in preclinical models of HER2+/PIK3CAmut breast cancer
购于瀚香生物(Biochempartner)的雷帕霉素(CAS:53123-88-9)被引用 |
结构式
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