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CAS号 | 53123-88-9 | 货号 | BCP01404 |
中文名 | 雷帕霉素 | ||
英文名 | Rapamycin | ||
中文别名 | 西罗莫司; | ||
英文别名 | Sirolimus;Rapamune; AY 22989; AY22989; AY-22989; WY090217; WY-090217; WY 090217; | ||
SMILES | C[C@@H](C([C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(C[C@@H]([C@H](C)C[C@@H]1CC[C@@H](O)C(OC)C1)OC2=O)=O)=O)C[C@H](C)/C=C/C=C/C=C(C)/[C@@H](OC)C[C@H]3O[C@](C(C(N4[C@H]2CCCC4)=O)=O)(O)[C@H](C)CC3 | ||
化学名称 | |||
分子式 | C51H79NO13 | 分子量 | 914.18 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | Rapamycin is a natural macrocyclic lactone produced by the bacterium Streptomyces hygroscopicus, with immunosuppressant properties. In cells, sirolimus binds to the immunophilin FK Binding Protein-12 (FKBP-12) to generate an immunosuppressive complex that binds to and inhibits the activation of the mammalian Target Of Rapamycin (mTOR), a key regulatory kinase. This results in inhibition of T lymphocyte activation and proliferation that occurs in response to antigenic and cytokine (IL-2, IL-4, and IL-15) stimulation and inhibition of antibody production. |
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