司马西特
| CAS号 | 425386-60-3 | 货号 | BCP01878 |
| 中文名 | 司马西特 | ||
| 英文名 | Semagacestat | ||
| 中文别名 | |||
| 英文别名 | LY450139;LY-450139;LY 450139; | ||
| 分子式 | C19H27N3O4 | 分子量 | 361.44 |
| 生物活性 | overexpressing human wild-type APP into the culture medium, with IC50 of 10.9 nM, 12.1 nM and 12.0 nM, respectively, without affecting cell viability. Semagacestat also increases β-CTF in cell lysates with ECmax of 16.0 nM, and the increase can be unexpectedly attenuated at high concentrations. Semagacestat inhibits Notch signaling with IC50 of 14.1 nM, and shows minimal Notch-sparing selectivity with Notch IC50/Aβ42 IC50 only 1.3.Semagacestat causes a concentration-dependent decrease in Aβ40 secreted into the medium with IC50 of 111 nM from murine CTX expressing endogenous murine APP, but murine Aβ42 formation in CTX is roughly 12-fold less than Aβ40 in accordance with data for neurons from wild type mice. | ||
| 信号通路 | Protease/Metabolic Enzyme Neuro Signaling Pathway Wnt/Stem Cell | ||
| 靶 点 | Gamma secretase Amyloid β Notch | ||
结构式
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