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Gamma secretase

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Gamma secretase

结构式 货号 产品名称 CAS号
Nirogacestat 结构式
 BCP24479 Nirogacestat 1290543-63-3
Nirogacestat is a potent and selective gamma secretase (GS) inhibitor with potential antitumor activity. PF-03084014 binds to GS, blocking proteolytic activation of Notch receptors. Nirogacestat enhances the Antitumor Effect of Docetaxel in Prostate Cancer. Nirogacestat enhances docetaxel-mediated tumor response and provides a rationale to explore GSIs as adjunct therapy in conjunction with docetaxel for men with CRPC (castration-resistant prostate cancer).
Begacestat 结构式
 BCP46406 贝加塞特 769169-27-9
Begacestat is a selective thiophene sulfonamide amyloid precursor protein gamma-secretase inhibitor (Aβ40,IC50=15 nM),and for the treatment of Alzheimer's disease.
MRK 560 结构式
 BCP43170 MRK 560 677772-84-8
MRK-560 is an orally bioavailable gamma-secretase inhibitor with the ability to markedly reduce Abeta peptide in the brain and CSF of the rat and confirm the utility of the rat for assessing the effects of gamma-secretase inhibitors on central nervous system Abeta(40) levels in vivo.
LY-411575 (isomer 1) 结构式
 BCP43166 LY-411575 (isomer 1) 209984-58-7
LY-411575 isomer 1 is an isomer of LY411575, which is a potent γ-secretase inhibitor.
CHF 5074 结构式
 BCP30410 CHF 5074 749269-83-8
CHF5074 is a novel γ-secretase modulator, reduces Aβ42 and Aβ40 secretion, with an IC50 of 3.6 and 18.4 μM, respectively.
PF-03084014 结构式
 BCP28117 PF-03084014 865773-15-5
PF-3084014 is a reversible, noncompetitive, and selective γ-secretase inhibitor with IC50 of 6.2 nM.
LY900009 结构式
 BCP27986 LY900009 209984-68-9
LY900009 is a small molecule inhibitor of Notch signalling via selective inhibition of the γ-secretase protein.
BMS299897 结构式
 BCP06241 BMS299897 290315-45-6
BMS-299897 markedly reduced both brain and plasma Abeta in APP-YAC mice with ED(50) values of 86 and 22 mg/kg per os (po), respectively.
Gamma-Secretase Modulators 结构式
 BCP12943 Gamma-Secretase Modulators 937812-80-1
Gamma-Secretase Modulators (Amyloid-β production inhibitor) is a Amyloid-β production inhibitor. Gamma-Secretase Modulators is useful for Alzheimer's disease.
NGP-555 结构式
 BCP25746 NGP-555 1304630-27-0
NGP555 is a γ-secretase modulator.
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