Linsitinib
| CAS No. | 867160-71-2 | Cat. No. | BCP01831 |
| Name | Linsitinib | ||
| Synonyms | OSI906;OSI 906;OSI-906; | ||
| Formula | C26H23N5O | M. Wt | 421.49 |
| Description | OSI-906 inhibits IGF-1R autophosphorylation and activation of the downstream signaling proteins Akt, ERK1/2 and S6 kinase with IC50 of 0.028 to 0.13 μM. OSI-906 enables an intermediate conformation of the target protein through interactions with the C-helix. OSI-906 displays favorable metabolic stability in liver microsomes. OSI-906 fully inhibits both IR and IGF-1R phosphorylation at a concentration of 1 μM. OSI-906 inhibits proliferation of several tumor cell lines including non-small-cell lung cancer and colorectal cancer (CRC) tumor cell line with EC50 of 0.021 to 0.810 μM. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase | ||
| Targets | Insulin Receptor IGF1R | ||
Structure
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