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Linsitinib Chemical Structure

Linsitinib

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP01831CAS No. ：867160-71-2Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 867160-71-2 Cat. No. BCP01831
Name Linsitinib
Synonyms OSI906;OSI 906;OSI-906;
SMILES
Chemical Name
Formula C26H23N5O M. Wt 421.49
Purity 98% Storage Store at 4-8°C
Description OSI-906 inhibits IGF-1R autophosphorylation and activation of the downstream signaling proteins Akt, ERK1/2 and S6 kinase with IC50 of 0.028 to 0.13 μM. OSI-906 enables an intermediate conformation of the target protein through interactions with the C-helix. OSI-906 displays favorable metabolic stability in liver microsomes. OSI-906 fully inhibits both IR and IGF-1R phosphorylation at a concentration of 1 μM. OSI-906 inhibits proliferation of several tumor cell lines including non-small-cell lung cancer and colorectal cancer (CRC) tumor cell line with EC50 of 0.021 to 0.810 μM.
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H-NMR LCMS
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