OSU-03012
| CAS No. | 742112-33-0 | Cat. No. | BCP01835 |
| Name | OSU-03012 | ||
| Synonyms | AR-12;N/AAR-12;OSU03012;OSU 03012; | ||
| Formula | C26H19F3N4O | M. Wt | 460.46 |
| Description | OSU03012; also known as AR12, is an orally available, targeted anti-cancer agent that has been shown in pre-clinical studies to inhibit PDK-1, a protein in the PI3K/Akt pathway that is involved in the growth and proliferation of cells, including cancer cells. AR-12 may also cause cell death through the induction of stress in the endoplasmic reticulum. We are currently conducting a multi-centered Phase I clinical study of AR-12 in adult patients with advanced or recurrent solid tumors or lymphoma. | ||
| Pathways | PI3K/Akt/mTOR | ||
| Targets | PDK | ||
Structure
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