OSU-03012
  • 化学数据
CAS号 742112-33-0 货号 BCP01835
中文名 OSU-03012
英文名 OSU-03012
中文别名
英文别名 AR-12;N/AAR-12;OSU03012;OSU 03012;
分子式 C26H19F3N4O 分子量 460.46
  • 用途
生物活性 OSU03012; also known as AR12, is an orally available, targeted anti-cancer agent that has been shown in pre-clinical studies to inhibit PDK-1, a protein in the PI3K/Akt pathway that is involved in the growth and proliferation of cells, including cancer cells. AR-12 may also cause cell death through the induction of stress in the endoplasmic reticulum. We are currently conducting a multi-centered Phase I clinical study of AR-12 in adult patients with advanced or recurrent solid tumors or lymphoma.
信号通路 PI3K/Akt/mTOR 
靶 点 PDK 

结构式

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